Endocrine Abstracts

Background: Although colonic polyps are associated with states of GH excess, no association with gastric polyps has been reported. We describe 2 patients who were treated with rhGH for non-GH deficient growth disorders and who were subsequently found to have gastric polyps.Patient 1: A girl aged 13.6 year with short stature was found to have Turner’s syndrome in the course of being investigated for abdominal pain, diarrhoea and rectal bleeding. Endo...

Background and aim: It is often proposed that growth retardation in IBD is associated with a state of growth hormone resistance but published data on the GH-IGF1 axis are scarce. We describe the results of routine clinical assessment of this axis in a group of such children.Methods: A retrospective study of 24 children with IBD (22 CD, 2 UC) with growth retardation and/or pubertal delay who underwent insulin tolerance test (ITT) following referral to the...

Background: A recent RCT of rhGH in IBD over 6 months showed that improvement in linear growth was associated with a reduction in insulin sensitivity.Objectives: To investigate the effects of prolonged rhGH on growth and glucose homeostasis in children with IBD.Patients and methods: Eleven children (10CD/1UC) (9 m) with a median age of 14.7 years (range, 8.9, 16.2) who received rhGH (0.067 mg/kg per day) as part a 6-month RCT were ...

Background: Despite optimal management, children with inflammatory bowel disease (IBD) may suffer from growth retardation. The role of rhGH in these children is unclear.Design: Randomised controlled trial of rhGH (0.067 mg/kg per day) for 6 months.Subjects: Twenty-two children with IBD and HtSDS<−2 or HtSDS<−1 and HVSDS<−1. Eleven were in the control group (C) and eleven in the treatment group (Rx).</p...